Sometimes an optional effect can only be activated "when" a condition happens. In this case, you are only allowed to activate the effect when the activation condition being met was the last thing to happen in the game. If something else happened after the activation condition was met, then you have missed the timing, and cannot activate the optional effect.
Now fore some examples
If Gusto Gulldo was destroyed by battle or by a card eff (Like dark hole) he can activate his eff in grave to SS Gusto level 2 or lower. If gusto gulldo is a cost to pay for a card like Icarus Attack It will miss timing Becouse there are stuff happening after he goes to grave so it will miss timing and will not activate his eff.If you use him for a tribute/synchro summon it Will miss timing.